Diastereoselective Pauson-Khand Reactions on Aromatic Substrates.

Abstract The synthesis of several natural products’ frameworks is carried out by means of a diastereoselective intramolecular Pauson–Khand reaction promoted by molecular sieves. Diastereoselectivity is achieved only if a coordinating group is present at a convenient distance from the alkene moiety. Naphthalenes can be obtained directly under refluxing toluene conditions.