Abstract 12149: Impact of Concomitant Administration Hypertonic Saline Solution and Daily Use Furosemide in Treatment of Acute Decompensated Heart Failure

Background While sodium infusion supplemented with furosemide is theoretically anticipated to promote diuresis in patients with acute decompensated heart failure (ADHF), there is little evidence to support this idea. The aim of this study was to investigate the effects of sodium infusion with daily use furosemide on ADHF. Methods Consecutive 44 patients with ADHF were enrolled in the study. Diagnosis of ADHF was performed on the basis of Framingham criteria. Forty four patients were alternately assigned to either the sodium infusion or the glucose infusion group. After hospitalization, patients were administered either continuous intravenous infusion of 500ml of 1.7%NaCl supplemented with furosemide 40mg (sodium infusion group) or continuous intravenous infusion of 500ml of 5% glucose supplemented with furosemide 40mg (glucose infusion group). All patients underwent physical examination of signs and symptoms for heart failure, measurement of supine blood pressure (BP) and heart rate (HR) at baseline and 2...