Clinical features and treatment of anti-neutrophil cytoplasmic anti-body (ANCA) associated vasculitis (AAV).

[Objective] To analyze the clinical manifestations and treatment of anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV) . [Methods] Retrospectively analysis was conducted to analyze the clinic data of 47 patients treated with ANCA associated vasculitis from April 2005 to April 2010 in our hospital. [Results] Among forty-seven patients,38 patients(80.9%,38 /47) were pANCA positive,and identified MPO. 8 patients(17.0%,8 /47) were cANCA positive,and identified by PR3. The cANCA and pANCA of one case were positive,and identified by MPO and PR3. 27 patients(57.4%,27 /47) were diagnosed within 6 months,and 20 cases were more than 6 months(42.6%,20 /47) . The clinical manifestations of ANCA associated vessel vasculitis was multiple organ involvement,including 43 cases of renal involvement(91.5%,43 /47) ,36 cases of serum creatinine(76.6%,35 /47) ,30 cases of lung involvement(63.8%,30 /47) and 16 cases of hemoptysis(34.0%,16 /47) . There were different levels of organ damaged,including the digestive system,joints,muscles,ears,eyes,skin,nervous system,nose and with non-specific performance. More than 80% of patients were with ESR speed up,C reactive protein and anemia. Glucocorticoids and cyclophosphamide treatment was mainly used,remission induction rate of total remission was 75.9%. [Conclusion] The clinical manifestations of ANCA associated vessel vasculitis was multiple organ involvement. ANCA detection was helpful in the early diagnosis.