Disruption of extracellular signaling
2020
Abstract Complex organisms rely on extracellular communication to control various physiological processes vital for development, maintenance, and reproduction. Most often, these signaling pathways are mediated by a signal molecule synthesized and released into the interstitial space by one cell that subsequently migrates and binds to a specific macromolecular receptor on/in a “target” cell. The signal–receptor interaction is transduced into a change in the target cell’s function, mediated by a variety of intracellular signaling events. A number of xenobiotics influence extracellular signaling events to elicit toxicity. This chapter is a brief overview of extracellular signaling and three general modes for xenobiotic-induced disruption of extracellular signaling.
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