Normal systolic function in hypertrophic cardiomyopathy: reality or myth?

We would like to thank Efthimiadis et al. for their interest in our work. Indeed, it was long believed that patients with hypertrophic cardiomyopathy (HCM) had normal or supranormal systolic function despite mutations in genes encoding for sarcomeric proteins. This concept was, at least partly, based on the use of endocardial indices of systolic function such as ejection fraction. Ejection fraction is generally normal or supranormal in HCM patients. However, it is well known that ejection fraction is a …