Preparation of Ambroxol hydrochloride sustained release tablet and determination of its dissolution rate

OBJECTIVE To prepare ambroxol hydrochloride sustained released tablets using HPMC and evaluate its releasing features in vitro.METHODS HPMC was utilized as matrix,70% ethanol was employed as a binding agent to obtain wet granules.The dissolution in different mediums were determined by UV spectrophotography.RESULTS The drug release behavior could be best described.CONCLUSION HPMC could be used as a matrix to prepare sustained-release tablet of ambroxol hydrochloride.