Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

Andy S. Tsai,Rebecca M. Wilson,Hitoshi Harada,Robert G. Bergman,Jonathan A. Ellman

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

2009

Andy S. Tsai
Rebecca M. Wilson
Hitoshi Harada
Robert G. Bergman
Jonathan A. Ellman

The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C–H bond functionalization with (S,S′,R,R′)TangPhos as the chiral ligand.

Keywords:

Alkylation
Enantioselective synthesis
Chiral ligand
Rhodium
Hydrogen bond
Catalysis
Enantiomer
Intramolecular force
Organic chemistry
Photochemistry
Chemistry
Inorganic chemistry
c h bond

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