Mechanistic Investigation of Pluronic® Based Nano-crystalline Drug-polymer Solid Dispersions

Feng Qian,Jing Tao,Sridhar Desikan,Munir A. Hussain,Ronald L. Smith

Mechanistic Investigation of Pluronic® Based Nano-crystalline Drug-polymer Solid Dispersions

2007

Feng Qian
Jing Tao
Sridhar Desikan
Munir A. Hussain
Ronald L. Smith

Purpose To understand the mechanism of nano-crystalline drug formation in Pluronic® (i.e., poly(ethylene oxide-block-propylene oxide) triblock copolymers) based drug-polymer solid dispersions.

Keywords:

Crystallization
Excipient
Poloxamer
Chemical engineering
Oxide
Polymer
Nano-
Copolymer
Polymer chemistry
Chromatography
Propylene oxide
Chemistry
Ethylene
Spray drying

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