Сравнительное исследование токсических свойств комплекса оксованадия и его металлохелатного лиганда

Aladyshkina The purpose of the work has consisted in comparative studying acute toxicity, cumulative activity of a new organic oxovanadium (IV) complex bis{tret-butyl[amino(imino)methyl]carbamato}oxydovanadium (IV) (BAMK) and his ligand tret-butoxycarbonylguanidine (BKG) and to the estimation of their influence on morphology of internals in comparison with vanadyl sulfate. Values of LD50 for the BAMK, BKG and vanadyl sulfate has averaged 178 mg / kg, 1003 mg / kg and 407 mg / kg correspondingly. According to the scale of Hodge and Sterner it is possible to attribute BAMK and BKG as the compounds with moderately toxic substances, and BKG – as compound with low toxicity. Because of research cumulation activity it has been shown, those БАМК and vanadyl sulfate have high cumulative activity, and BKG does not cumulate in internals of animals.