Retarded decline of the share of SARS-CoV-2-positive children in North Rhine-Westphalia, Germany

Abstract Knowledge on the mechanisms of viral spread, of time-related changes and age-specific factors of SARS-CoV-2 infections is important to develop recommendations aimed at controlling the pandemic In this context, longitudinal data on proportions of positive results in different age groups are rare Data on total positive counts and on shares of positive counts deriving from a private (MVZ) and a University (RWTH) laboratory were analyzed retrospectively and compared with public data on total positive counts of the Robert Koch Institute (RKI) Data covered weeks 9 to 24 of the year 2020 and all patient ages Total positive counts were lower in children compared to adults Proportions of children and adults tested positive were 3-5% and 5-7%, respectively RKI and MVZ data showed similar time-related patterns Patients of 20 to 60 years of age did account for the initial virus spread (maximum infection rates at weeks 9-11) Thereafter infection rates decreased in older patients whereas children did not show a comparable time-related decrease Pediatric data generated in outpatient settings and hospitals differed markedly which should be considered in further studies In summary, compared with adults children are less affected by SARS-CoV-2 infections and are unlikely to account for the initial viral spread However, children show sustained viral activity and may serve as a viral reservoir This article is protected by copyright All rights reserved