[TGF-beta and its receptors].
1997
: TGF-beta is a member of a superfamily associated with development and regulation of cell growth. Recently, its two receptors and intracellular components of signal transduction, a Smad family, have been identified. The type II receptor gene has been found to be mutated specifically in hereditary colon cancers, HNPCC. Alterations of the Smad 4 gene were also detected in pancreatic and colorectal cancers.
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