An experimental study of the cardiovascular activity of nistranol
1997
: In concentrations of > or = 10(-5) mol/liter nistranol (11 beta-nitroxy-9 alpha-hydroxy-ethynylestradiol-diacetate) demonstrated cardiac and vascular activity in vitro. It caused concentration-dependent and reversible increase of the contractile parameters of an isolated atrial appendage of rats. A three-phase effect of nistranol on a isolated rat thoracic aorta was encountered: vasodilatation-vasoconstriction-vasodilatation. Anti-ischemic and antinecrotic effects of nistranol were noted in experimental myocardial infarction.
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