Preparation technology of doxycycline hydrochloride for injection

The invention discloses a preparation technology of doxycycline hydrochloride lyophilized powder for injection. The doxycycline hydrochloride prepared by the invention reduces the contents of toxicants including Beta-doxycycline and metacycline; the doxycycline hydrochloride for injection prepared from an injection-grade doxycycline hydrochloride is characterized by low acrimony, low irritabilityand low adverse reaction. The injection-grade doxycycline hydrochloride can be used for preparing medical preparation for intravenous injection, such as the doxycycline hydrochloride powder injection,lyophilized powder injection and injection liquid for in vivo injection and medication, and has the advantages of low acrimony, low irritability, low adverse reaction and the like.