Adreral lesions inpatients of multiple endocrine neoplasia type 1

：Objective To investigatethe prevalence and characteristics of adrenal lesions in Chinese multiple endocrineneoplasia type 1 (MEN-1) patients. Methods Adrenal CT scan and clinical manifestationswere retrospectively reviewed in 32 consecutive MEN-1 patients who were evaluated at ourhospital during January 1986 to December 2009. Results Adrenal lesions were identified in16 of 32 (50%) MEN-1 patients. Five (31.3%) patents with adrenal involvement showedbilateral lesions, including bilateral adenoma (n= 1), bilateral hyperplasia (n= 2) andadenoma and hyperplasia on each side (n= 2). Unilateral adrenal lesion was presented in 11(68.7%) patients. Among which, 63.6% had adenomas with a mean diameter of 2.3 cm (0.8 -4.0 cm) and the remainder was of hyperplasia or enlargement. In two patients, functioningadrenal abnormalities were detected including Cushing adenoma (n= 1) andaldosterone-secreting adenoma (n= 1). Conclusions The prevalence of adrenal lesion inMEN-1 patient is similar between China and western countries. These tumors are mostlybenign, small and nonfunctioning. Taking into account a high incidence of adrenalcarcinoma in previous foreign studies,rourine screening and close surveillance are stillrecommended for adrenal lesions in MEN-1 patients.