Effects of Administration of Proton Pump Inhibitor Before Endoscopic Submucosal Dissection for Differentiated Early Gastric Cancer With Ulcer

Tu1725 Predilection Sites of Intestinal Metaplasia in the Stomach: a Retrospective Study Based on Endoscopic Results of 78,335 Cases Xin-Yi Mao, Qing Liu, Hai-Han Zhang, Shun-Fu Xu, Jian-Xia Jiang* Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Objectives: Gastric intestinal metaplasia (IM) is closely related to the occurrence of intestinal-type gastric carcinoma. This research was aimed to study the predilection sites of IM in the stomach to guide endoscopic biopsy selection to find IM as early as possible, and decrease the canceration rate of stomach ultimately. Methods: Totally 78,335 cases receiving gastroduodenoscope examination, who came from Jiangsu and Anhui provinces of China during 2008-2013, were enrolled in the study. The basic characteristics, biopsy sites and histological information were obtained and analyzed. This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University and the committee specifically approved and no informed consent was required since these data were going to be analyzed anonymously. Results: The study showed that IM incidence rate 40% (2,068/6,345) in angulus, 20.24% (11056/54632) in lesser curvature of antrum and 25.48% (276/1083) in corpus, which are significantly higher than other sites in the stomach (P!0.005) (Table 1). Moreover, the severity of IM in lesser curvature of antrum and angulus were worse than great curvature of antrum (Table 2). Furthermore, the severity of acute and chronic inflammation were both higher in lesser curvature than in great curvature of antrum regardless of H. pylori-positive and negative (P!0.05). Conclusion: IM was mostly prone to occur in angulus, the lesser curvature of antrum and corpus. And the severity of inflammation in the lesser curvature of antrum was also higher than the great curvature, which was partially consisting with IM predilection site. Our conclusion was that angulus, the lesser curvature of antrum and corpus should be chosen as regular biopsy sites.