Pyridine as a Tripeptidomimetic Scaffold

There are several short peptides that are biologically active and hence of interest for drug development. One major limitation preventing oral administration of these compounds is the instability of amide bonds towards enzymatic degradation. Therefore, compounds that mimic the effect of peptides but lack the peptide structure are of great interest [1]. One approach towards so called peptidomimetics is to use a cyclic structure as a scaffold to which different pharmacophoric groups, supposedly amino acid side chains, can be attached.