Patch-Clamp Recording of Voltage-Sensitive Ca2+ Channels
2014
In this article, we focus on a refinement of the traditional voltage-clamp methods that are used to measure current from whole cells, or relatively large areas of membrane, called the patch-clamp technique. Although this technique has extended the application of voltage-clamp methods to the recording of ionic currents flowing through single channels, in its whole-cell configuration it has become the most widely used method for recording ionic currents. We give particular attention to the study of voltage-gated (CaV) Ca 2+ channels using the patch-clamp technique and discuss some aspects of the molecular physiology of these proteins.
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