Homologs of VEGF polypeptides and BMP1

Antibody antagonist anti-VEGF-E for use in a method of treating cancer in a mamiferomediante administration serially or in combination with a second agent, and either in the same composiciono in separate compositions, where VEGF-E is the VEGF -E length native sequence completaque comprises amino acids 1-345 as illustrated in Figure 2 or a osecretada truncated forms of natural origin or alternatively processed or allelic thereof, and wherein the antibody antagonizes one or more of the following activities of VEGF-E: (i) stimulation of selective growth and / or survival of endothelial cells human umbilical lavena; (ii) induction of c-fos immediate early gene in human endothelial cell lines; (iii) induction of myocyte hypertrophy in cardiac cells; or (iv) inhibition of VEGF stimulated proliferation of endothelial cells capilarescorticales adrenals.