Characterization of Sitagliptin Use in Patients with Type 2 Diabetes and Chronic Kidney Disease by Cross-Sectional Analysis of a Medical Insurance Claims Database

Introduction Chronic kidney disease (CKD) is common in patients with type 2 diabetes (T2DM) and makes them particularly susceptible to safety/tolerability issues related to many classes of oral antihyperglycemic agents (OAHA). Dipeptidyl peptidase-4 inhibitors (DPP-4is) like sitagliptin are generally well tolerated in patients with T2DM and renal disease and therefore may be preferentially used in patients with CKD. To assess the extent of this preference, the characteristics of sitagliptin users with T2DM and CKD were compared with those of other (non-DPP-4i) OAHA users with T2DM and CKD.