New Insights on the Simultaneous Assessment of Insulin Sensitivity and β-Cell Function With the HOMA2 Method Response to Caumo et al.

We read the article by Caumo et al. (1) with great interest. Using homeostasis model assessment (HOMA), they have simultaneously assessed insulin sensitivity (HOMA-S%) and β-cell function (HOMA-B%) by using the HOMA2 method (2) in a group of 76 normoglycemic subjects with or without obesity. They found the HOMA scatter plot to be reminiscent of the hyperbolic relationship previously reported using acute insulin response and insulin sensitivity index calculated by minimal model analysis of intravenous glucose tolerance testing (3). From their HOMA scatter plot, they also proposed the unique disposition index (DI), …