A Nationwide Population Based Analysis of Organ-Confined Muscle-Invasive Bladder Cancer Patients Not Receiving Curative Intent Therapy in Sweden from 1997 to 2014.

AbstractPurpose:While radical cystectomy remains the standard treatment for muscle-invasive bladder cancer, the natural history of patients unable or unwilling to receive curative intent therapy (CIT) is not well understood. The study objective was to identify these patients in a population-based cohort and investigate the clinical profile and describe time to mortality.Material and Methods:BladderBaSE, a database collected 1997-2014 was analyzed. 9 811 patients with stage T2-T4 were identified. Median overall survival (MOS), and cancer specific survival was estimated using Kaplan-Meier methods. Relative risks due to prognostic factors were estimated using Cox proportional hazards models.Results:5 592 patients did not receive CIT; 68% were male and 32% were female. The median ages were 79 and 81 years, respectively. After one year, patients had been hospitalized on average 18.8 days (2.1 times). Major and minor urologic surgery were the most commonly registered procedures during these hospitalizations. MO...