Stimulation of functional neuronal regeneration from Müller glia in adult mice

Nikolas L. Jorstad,Matthew S. Wilken,William N. Grimes,Stefanie G. Wohl,Leah VandenBosch,Takeshi Yoshimatsu,Rachel Wong,Fred Rieke,Thomas A. Reh

Stimulation of functional neuronal regeneration from Müller glia in adult mice

2017

Nikolas L. Jorstad
Matthew S. Wilken
William N. Grimes
Stefanie G. Wohl
Leah VandenBosch
Takeshi Yoshimatsu
Rachel Wong
Fred Rieke
Thomas A. Reh

Inhibition of histone deacetylation allows the transcription factor Ascl1 to bind to key gene loci in Muller glia and drive the functional generation of retinal neurons in adult mice.

Keywords:

Acetylation
Transcription factor
ASCL1
Molecular biology
Locus (genetics)
Gene
Histone
Retinal
Genetics
Biology
Muller glia
Cell biology
Histone deacetylase
Zebrafish
Histone deacetylase inhibitor
Retina
Neurogenesis

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