Accelerated Bone Formation Around Titanium Dental Implants with Amorphous Calcium Phosphate Coating in Rabbits

The aim of this study was to investigate the bone response of titanium dental implant with amorphous calcium phosphate (ACP) coating film fabricated using RF magnetron sputtering in rabbit. Calcium phosphate coating using RF magnetron sputtering acquires high bonding strength and nano-uniformity of films. Moreover, it is reported that ACP was resorbed rapidly in vitro. The ACP-coated and non-coated implants were placed into rabbits. After 1, 2 and 4 weeks of implantation, the implant stability was evaluated by resonance frequency analysis (RFA) and bone formation was also evaluated histomorphometrically. The ACP-coated implants showed higher stability in RFA and improved bone-implant contact ratio in 4 weeks. Titanium dental implant coated with ACP fabricated using RF magnetron sputtering accelerated bone formation compared with that of non-coated implants.