Utilizing porcupine (PORCN) and DKK1 inhibition to improve anti-tumor immunity in a murine model of ovarian cancer.

Jaclyn A. Wall,Ashwini A. Katre,Selene Meza-Perez,Angelina I. Londono,Lyse A. Norian,Rebecca C. Arend

Utilizing porcupine (PORCN) and DKK1 inhibition to improve anti-tumor immunity in a murine model of ovarian cancer.

2020

Jaclyn A. Wall
Ashwini A. Katre
Selene Meza-Perez
Angelina I. Londono
Lyse A. Norian
Rebecca C. Arend

e18041Background: Epithelial ovarian cancers (EOC) are immunologically “cold” tumors and consequently have seen limited success with immunotherapy. Wnt-beta/catenin signaling is dysregulated in mul...

Keywords:

murine model
antitumor immunity
DKK1
PORCN
Ovarian cancer
Pathology
Porcupine
Cancer research
Medicine

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