Transfusion and Morbi-Mortality Factors: An Observational Descriptive Retrospective Pediatric Cohort Study

Background Intraoperative and postoperative morbi mortality factors are multiple in pediatric patients Studies in pediatric cardiac surgery and intensive care patients have identified transfusion as one independent factor among others There is not a lot of data concerning transfusion related morbi mortality in other pediatric patients fields like neurosurgery abdominal and orthopedic surgery These were investigated Objectives To identify morbi mortality risk factors in intraoperatively transfused and not transfused pediatric patients in neurosurgery abdominal and orthopedic surgery Design Retrospective observational descriptive pediatric cohort study Setting Monocentric pediatric tertiary center Necker Enfants Malades University Hospital Paris from January to Mai Patients patients with mean age of plusmn months were included nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Inclusion criteria were the presence or the absence of transfusion in the intraoperative period in neurosurgery abdominal and orthopedic surgery patients nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp Exclusion criterion was transfusion in the postoperative period until discharge from hospital Main outcome measures Primary outcome was mortality and secondary outcome was morbidity in transfused and non transfused patients Mortality was assessed by deaths occuring intraoperatively or postoperatively during the entire hospitalisation Morbidity was assessed by intraoperative postoperative complications repeat surgery length of stay in the intensive care unit in the hospitalisation ward total length of stay in hospital and length of mechanical ventilation Results Multivariate analysis revealed that ASA score was the independent risk factor for mortality Transfusion emergency surgery type of surgery age and prematurity were independent risk factors for morbidity Conclusion Patient outcome can be improved by applying specific preventive measures on each risk factor