Long Term Treatment with Low Dose Testosterone in Constitutional Delay of Growth and Puberty: Effect on Bone Age Maturation and Pubertal Progression

: We compared the effects of long term low dose treatment with testosterone on pubertal growth and sexual development in boys with constitutional delay of growth and puberty (CDGP). We treated 24 boys with intramuscular monthly injections with low dose testosterone enanthate (33-50 mg) for 20 months, at a chronological age of 14.5 +/- 1.0 years and SDS height of -3.31 and compared their response to a group of 14 control boys. Treated patients showed an earlier and significant increase in height velocity compared to controls, 10.1 vs 4.0 cm/year, while the latter group showed their growth spurt twelve months later. Both groups showed an initial acceleration in bone age without impairment of predicted adult height. During the first 12 months of treatment the increment of testicular volume in the treated patients was slightly slower than controls; however the earlier the puberty, the slower the testicular increment compared to controls. We conclude that treatment of boys with constitutional delay of growth with low dose testosterone is effective in improving their height velocity without impairment of predicted final height. Progression of testicular volume during treatment in some patients is more delayed; however, after treatment it increased normally.