Dietary calcium to phosphorus ratio affects postprandial phosphorus concentrations in feline plasma.

The impact of dietary phosphorus on chronic renal disease in cats, humans and other species is receiving increasing attention. As calcium (Ca) and phosphorus (P) metabolism are linked, the ratio of Ca:P is an important factor for consideration when formulating diets for cats and other animals. Here, we describe a fully randomized crossover study including 24 healthy, neutered adult cats, investigating post-prandial responses in plasma P, ionised Ca (iCa) and parathyroid hormone (PTH) following one meal (50% of individual metabolic energy requirement) of each of six experimental diets. Diets were formulated to provide P at either 0.75 or 1.5 g/1000kcal (4184kJ) from the soluble phosphorus salt sodium tripolyphosphate (STPP, Na5P3O10), variable levels of organic Ca and P sources, and an intended total Ca:P of ∼1.0, 1.5 or 2.0. For each experimental diet, baseline fasted blood samples were collected prior to the meal, and serial blood samples collected hourly for 6 hours thereafter. For all diets, a significant increase from baseline was observed at 120mins in plasma PTH (p<0.001). The diet containing the highest STPP inclusion level and lowest Ca:P induced the highest peaks in post-prandial plasma P and PTH levels (1.8mmol/l and 27.2pg/ml, respectively) and the longest duration of concentrations raised above baseline were observed at 3 hours for P and 6 hours for PTH. Data indicate that Ca:P modulates postprandial plasma P and PTH. Therefore, when formulating diets containing soluble P salts for cats, increasing the Ca:P ratio should be considered.