Poor sleep in PCOS; is melatonin the culprit?

main results and the role of chance:PCOS women had significantly elevated night-time urinary levels of the melatonin metabolite 6-sulfatoxymelatonin (aMT6s) and of 8-OHdG (both at P , 0.05), as well as significantly reduced sleep quality (P , 0.05), compared with the controls. limitations, reasons for caution: Due to the small sample size of the study, further studies will be required to confirm our findings. wider implications of the findings: Our preliminary work provides a possible new insight into the interactions between melatonin, increased oxidative stress and sleep in women with PCOS.