miR-145-5p inhibits psoriasis progression by regulating the Wnt/β-catenin pathway.

OBJECTIVE This research aimed to probe into the effect of miR-145-5p in psoriasis by regulating Wnt/β-catenin. METHODS A total of 45 psoriasis patients treated in our hospital were enrolled into an observation group (OG), and other 40 healthy individuals in physical examination over the same period were enrolled into a control group (CG). miR-145-5p in both groups was quantified, and its value in diagnosis and recurrence prediction of psoriasis was analyzed. Additionally, miR-145-5p was transfected into HaCat cells to analyze the biological behaviors of transfected cells, and factors for Wnt/β-catenin pathway inhibition were injected into cells to detect its protein expression in the cells, so as to verify the regulation of miR-145-5p on the Wnt/β-catenin pathway. RESULTS with low expression in the serum of psoriasis patients (P 0.05); but compared with both groups, the miR-145-5p-mimics group showed lower proliferation activity, higher apoptosis rate, and higher expression of Wnt3a, Wnt5a, and β-catenin proteins (all P<0.05). CONCLUSION Up-regulating miR-145-5p can activate the Wnt β-catenin signal pathway, thus inhibiting psoriasis progression.