OA02-06 LB. Recombinant modified Vaccinia virus ankara expressing HIV-1 genes activates NK subset capable of controlling HIN infection in vitro

Background Primate innate immune mechanisms are critical for the normal development of adaptive immune responses to antigen. Part of the modern effort to design and distribute vaccines against pathogens must involve detailed descriptions of innate responses resulting from vaccine challenges. Particularly, the interaction between Natural Killer (NK) and Dendritic cells is expected to greatly impact the establishment of both innate and adaptive immune responses to vaccine. In this study, we describe responses of Natural Killer cells to recombinant Modified Vaccinia Virus Ankara expressing HIV-1 genes (rMVA) compared to wild type MVA (MVAwt).