THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY

This investigation discussed the role of curcumin and flaxseed in defeating induced solid tumours with the subcutaneous inoculation of mice with Ehrlich Ascites Carcinoma (EAC) in a definite volume (3X106 cells). Once the tumours were formed, the mice were divided into four groups (control, tumour untreated, curcumin and flaxseed) groups. Each group contains six mice. By the end of experimentation (28 days) after tumour formation, mice were dissected and histological examination for liver and kidney were performed in all groups. Also, the levels of liver functions (ALT & AST), kidney functions (Urea & Creatinine), oxidant and antioxidant enzymes (MDA, SOD and CAT) were measured in all tested groups. This study could state that Curcumin and flaxseed modulated the histological structures of both liver and kidney close to normal patterns. Also, treatments could modified the elevated values of (ALT, AST, Urea, Creatinine and MDA) and decreased levels of (SOD and CAT) towards the normal values. Treatments with Curcumin and flaxseed also reduced the tumour volumes significantly.