Synchronous intermittent mandatory ventilation modescompared withpatient triggered ventilation during weaning

1995 
The efficacy of combiningrateand pressurereduction duringweaningby synchronousintermittent mandatory ventilation (SIMV)werecomparedwith weaningbypatient triggered ventilation (PTV)(pressure reduction alone) intwo randomised trials. Regardless ofventilationmode,pressure wasreducedtothe samelevelaccording tothesizeofthe infant. Inthefirst trial, theSIMV rate was alsoreducedprogressively to a minimum of20breaths/minute, andin thesecondtofivebreaths/minute. Forty premature infants aged15daysofageor lesswererandomlyallocated intoeach trial. No significant differences were foundinthefirst trial betweenventilation modesineither theduration ofweaning or the number of infantsin whom weaningfailed. Inthesecondtrial, the durationof weaningwas shorterby PTV thanby SIMV (median24hours, range7-432v 50hours,range12-500; p
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