Prefrontal cortex magnetic stimulation, a simulation analysis

The presented work aims to elucidate where stimulation occurs in the brain during transcranial magnetic stimulation (TMS), taking into account cortical geometry. A realistic computer model of TMS was developed comprising a stimulation coil and the human cortex. The coil was positioned over the right dorsolateral prefrontal cortex (right DLPFC) and the distribution of the induced electric field was analyzed. A computer simulation was constructed, where the coil is positioned at an angle of 450 relative to the sagittal plane. The results highlight the influence of cortical geometry on the distribution of the electric field in the brain and show that the highest values are not obtained directly under the center of the stimulator.