UVB stimulates production of enkephalins and other neuropeptides by skin-resident cells.

While studies on the ultraviolet B (UVB)-induced expression of proenkephalin (PENK) in murine regulatory T (Treg) cells with their possible role in regulation of skin homeostasis (1) are of interest, several very important issues have to be addressed to establish their significance. First, PENK is expressed and processed to the final opioid peptides including Leu- and Met-enkephalins in the resident skin cells such as keratinocytes, melanocytes, and fibroblasts, and this expression and production … [↵][1]1To whom correspondence may be addressed. Email: aslominski{at}uabmc.edu, chanderraman{at}uabmc.edu, or rslominski{at}uabmc.edu. [1]: #xref-corresp-1-1