CD105 inhibits transforming growth factor-beta-Smad3 signalling

CD105 (endoglin) is an important component of the transforming growth factor-‚ (TGF-‚) receptor complex and is highly expressed in endothelial cells in tissues undergoing angiogenesis such as healing wounds, infarcts and in a wide range of tumours. In an attempt to understand the molecular mechanism by which CD105 exerts its effects on angiogenesis by modulating TGF- ‚1 signalling, in this preliminary communication, CD105