Comprehensive surgical management of cherubism with orbital involvement

Abstract Cherubism is a hereditary childhood disease of autosomal dominant inheritance. It is more common in males. Its main clinical characteristic is a painless symmetrical swelling of the jaws with polycystic destruction of the bone structure and dental anomalies causing malocclusion. It is a self-limited disease, and some cases of spontaneous regression have been reported. Two clinical cases with remarkable orbital involvement are presented and the surgical management is described. Preprosthetic surgery and dental rehabilitation with osseointegrated implants was also carried out for the first patient. Surgery resulted in a significantly improved functional and aesthetic outcome for both patients, with no complications and a stable clinical situation on follow-up. Cherubism is a rare, non-neoplastic disease affecting the jaws but also the orbits. Facial deformity, malocclusion and visual impairment set the need for a multidisciplinary team approach in order to get successful outcomes in means of function and aesthetics.