SARS-CoV-2 Enfeksiyonu (COVID-19) ve Güncel Tedavi Yaklaşımları

SARS-CoV-2 infection (COVID-19), emerged in Wuhan, China in December 2019, has turned into a pandemic in time which is causing to the losses of many people and continuing its effect. This pandemic has stimulated the scientific development of severe acute respiratory syndrome (SARS-CoV) in 2002-2003 and the Middle East respiratory syndrome (MERS-CoV) in 2012 and it has accelerated the development of our understanding of the epidemiology, pathogenesis, therapeutic approaches and vaccination of SARS-CoV-2. It difficult to against for control of disease because the lack of direct specific antiviral drugs and vaccines, and such as rapid spread of disease factors led to the use of alternative supportive therapeutics. Currently, researching on various antiviral and immunomodulating agents are in various stages, continuing in vitro or clinical trial all over the world that can be used against this infection. Some antiviral agents targeting various other diseases are used for SARS-CoV-2 infection, giving successful results about attachment of the virus to the host cell, or replication. Application of antibiotics helps to control the infection in patients with coinfection cases. Teicoplanin and its derivatives are reported to be potential inhibitors of COVID-19. Monoclonal antibodies are used to inhibition the binding of host cell angiotensin converting enzyme 2 receptors with the spike protein (S) on the coronaviruses. In addition, corticosteroids and herbal medications are applied as optional supportive therapeutic approache for COVID-19. This review provides a comprehensive summary presentation on the agent, transmission, pathogenesis, clinical signs, diagnosis, control, and current therapeutic approaches of the SARS-CoV-2 infection.