Complicated case of Paget disease after nipple conservative operation of mammary cancer with multiple Bowen disease.

We report herein a case of mammary Paget's disease complicated by multiple Bowen's disease in a patient who had received successive chemotherapy during follow-up for surgical resection of breast cancer preserving the nipple 8 years earlier.Subject: The patient was a 52-year-old housewife.In 1988, she underwent left breast cancer resectomy preserving the nipple at another hospital.In 1991, erosion on the left nipple was noted.In 1993, erythema on the inner portion of the right breast was noticed.In 1995, since erosion of the left nipple expanded to the areola and was accompanied by gradual extension of erythema on the inner portion of the right breast as well as dispersion of erythema on other parts of the trunk, the patient consulted a local dermatologist.Because Bowen's disease was diagnosed by biopsy of the left areola with erythema due to suspected Paget's disease, the patient was reffered to our hospital.At our department, biopsy of the left areola as well as the erythematous area of the trunk was performed again.On histopathological examination, the patient was diagnosed with mammary Paget's disease and multiple Bowen's disease.The findings of the biopsy performed at the other hospital also indicated Paget's disease.