The clinical spectrum of organ manifestations of tuberous sclerosis

Since the first description of the classic triad of adenoma sebaceum, epilepsy and mental retardation by Vogt, various manifestations have been added to the clinical picture of Bourneville-Pringle disease or tuberous sclerosis. Diagnosis, therapy and potential complications of the more frequent manifestations are summarized. Since even oligosymptomatic patients may develop dangerous complications, the importance of thorough examination is emphasized.