Magnesium chloride or magnesium sulfate: a genuine question

MgSO 4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO 4 and MgCl 2 effects in order to answer the question whether MgSO 4 could be or not replaced by MgCl 2. Considering that the two salts have both similar and proper effects, a clear-cut conclusion is not easy to draw. However, choosing MgCl 2 seems advisable because of its more interesting clinical and pharmacological effects and its lower tissue toxicity as compared to MgSO 4.