Le Test De Tolerance Au Chlorpropamide Intraveineux

SummaryA single dose of 500 mg of chlorpropamide was injected intravenously in each individual of a group of 62 subjects including I0 normal individuals without a familial history of diabetes.The drug induced a mean fall of 25 to 30 % in fasting blood glucose level in the normal subjects. This drop did not amount a mean value of 20 % in patients with true diabetes, latent diabetes or chronic pancreatitis. Contrastingly, in a case of insulinoma, the drug markedly enhanced the hypo-glycaemic tendencies.It is concluded that the intravenous chlorpropamide test is useful for studying the endocrine function of the pancreas. This test can detect latent diabetes as well as pancreatic insulinoma.