Study of Serum Dickkopf-1, and Golgi Membrane Protein in Egyptian Patients with Colorectal Cancer

Background: Colorectal cancer is considered as a major cause of morbidity and mortality throughout the world. Colonoscopy is highly sensitive and specific for detection of lesions. It is likely that the combination of screening methods is more effective than the use of any methodalone. Serum Dickkopf-1 (DKK1) and Golgi membrane protein (GP73) has emerged as a promising biomarker for colorectal cancer diagnosis. However, their diagnostic accuracy is quite variable Aim of the work : to study serum Dickkopf-1, and Golgi membrane protein in Egyptian patients with colorectal cancer as well as their correlation to CEA, CA 19-9 & other -biochemical parameters and determine the possibility to use them as a diagnostic tool for colorectal cancer. Patients and methods: This study included 30 patients divided into 2 groups: group I: comprised 15 patients with CRC, group II: comprised 15 patients with other colorectal disease together with 15 healthy control. The diagnosis was established on the basis of history, clinical, laboratory, endoscopic and histological data. CBC, ESR, liver, kidney function tests, CEA, CA 19-9, were also done. Results: There was highly significant increase in DKK1 in group I, II in comparison to control group with no significant difference between group I, group II and no significant difference in GP73 between the studied groups. There was highly significant decrease in Hg& increase in ESR level in GI in comparison to control group while no significant difference in WBCs was detected among the studied groups.In GI there were significant positive correlations between GP73 levels, Hg, RBCs, ESR while in GII a significant positive correlation between GP73 levels & CA19-9 and between DKK1& CEA was found. Conclusion s : DKK1 is involved in the pathogenesis of colorectal diseases including colorectal cancer but the exact value of serum DKK1 & GP73 as a diagnostic tool for colorectal cancer requires additional investigation.