Large sample confidence intervals for regression standardized risks, risk ratios, and risk differences

Abstract Several methods have been proposed for standardizing risks, risk ratios, and risk differences based on the results of logistic regression. These methods provide an alternative to direct standardization, a particularly useful approach when there are many covariates. In this paper, methods for calculating approximate confidence limits for these standardized measures are presented. A simple example, in which published data are used, illustrates the techniques and allows comparison with confidence limits calculated from the directly standardized risk ratio.