Deoxyspergualin in relapsing and refractory Wegener's granulomatosis
2009
Objectives: Conventional therapy of Wegener’s granulomatosis with cyclophosphamide and corticosteroids is limited by incomplete remissions and a high relapse rate. The efficacy and safety of an alternative immunosuppressive drug, deoxyspergualin, was evaluated in patients with relapsing or refractory disease. Methods: A prospective, international, multi-centre, single limb, open label study. Entry required active Wegener’s granulomatosis with a Birmingham Vasculitis Activity Score (BVAS) ≥4 and previous therapy with cyclophosphamide or methotrexate. Immunosuppressive drugs were withdrawn at entry and prednisolone doses adjusted according to clinical status. Deoxyspergualin, 0.5mg/kg/day, was self-administered by subcutaneous injection in six cycles of 21 days with a seven day washout between cycles. Cycles were stopped early for white blood count Results: 42/44 patients (95%) achieved at least partial remission and 20/44 (45%) achieved complete remission. BVAS fell from 12 (4-25), median, range; at baseline to 2 (0-14) at the end of study (p Conclusions: Deoxyspergualin achieved a high rate of disease remission and permitted prednisolone reduction in refractory or relapsing Wegener’s granulomatosis. Adverse events were common but rarely lead to treatment discontinuation.
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