Studies on chemically modified fibrinogen. II. Physicochemical properties of maleylated fibrinogen

Abstract Modification of up to 60% of epsilon-amino lysine residues in fibrinogen molecule with maleic acid anhydride does not change hydrodynamic properties of fibrinogen molecule. Some small differences in its optical properties could be observed. Total modification leads to the gelification of fibrinogen preparation and to increased stability to the proteolytic action of plasmin and trypsin.