Dyneinopathy: From Animal Model to Human Beings

Cytoplasmic dynein, the only retrograde transporter in eukaryote cells, plays an important role in cellular life. The dynein gene mutations usually lead to severe disorder or death. With the understanding for cytoplasmic dynein's structures and functions, its relationships with nervous system degenerative disease become more and more clear. It was reported that there are dynein gene mutations in patients with Charcot-Marie-Tooth disease and motor neuron disease. For the close relationship between cytoplasmic dynein and some concrete neurodegeneration disease, the new disease was defined as dyneinopathy. In this review, some novel research progresses about cytoplasmic dynein both in animal models and human beings were discussed.