Methylprednisolon minimiert im Rattenmodel die Ischämie/Reperfusionsschädigung der Leber durch Reduktion von Apoptose und Inflammation

Introduction During hepatectomy, temporary hilar occlusion is sometimes necessary to reduce the risk of intraoperative bleeding. Hereafter, the associated ischemia/reperfusion (IR) injury may lead to hepatocellular damage, which might result in postoperative organ dysfunction and organ failure. The aim of our study was to evaluate the protective efficacy of steroid administration prior to hepatic ischemia, and the potential underlying mechanisms.