Similar distribution of monoamine oxidase (MAO) and parkinsonian toxin (MPTP) binding sites in human brain

1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) causes parkinsonism in humans and other species. We found [ 3 H] MPTP binding sites that were saturable, specific, and of high affinity. In autoradiographic studies, the highest binding densities of [ 3 H] MPTP occurred in the hypothalamus, interpeduncular nucleus, and ependymal lining of the ventricles. High to moderate binding was seen in the dentate gyrus, caudate, put0amen, substantia nigra, and cingulate cortex. The distribution of [ 3 H] MPTP binding correlated with the distribution of [ 3 H] pargyline binding to MAO. Human substantia nigra contains more MPTP binding sites than rat substantia nigra, and this may explain the sensitivity of humans to the neurotoxic effects of MPTP.