Thermal Sensitive Liposomes Improve Delivery of Boronated Agents for Boron Neutron Capture Therapy

Micah Luderer,Barbara Muz,Kinan Alhallak,Jennifer Sun,Katherine Wasden,Nicole Guenthner,Pilar de la Puente,Cinzia Federico,Abdel Kareem Azab

Thermal Sensitive Liposomes Improve Delivery of Boronated Agents for Boron Neutron Capture Therapy

2019

Micah Luderer
Barbara Muz
Kinan Alhallak
Jennifer Sun
Katherine Wasden
Nicole Guenthner
Pilar de la Puente
Cinzia Federico
Abdel Kareem Azab

Purpose Boron neutron capture therapy (BNCT) has the potential to become a viable cancer treatment modality, but its clinical translation requires sufficient tumor boron delivery while minimizing nonspecific accumulation.

Keywords:

Radiochemistry
Drug delivery
Chemistry
Neutron capture
Liposome
Boron
Chromatography
thermal sensitive
tumor retention
cancer treatment
mild hyperthermia

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