Efficient synthesis and biological evaluation of bis dispiro imidazolidines through 1,3-dipolar cycloaddition reaction

ABSTRACTA highly efficient and milder protocol for the synthesis of dispiro imidazolidines in good yields through 1,3-dipolar cycloaddition of in situ-generated azomethine ylide from different di/tri ketones and secondary amino acids with bisimine has been developed. The structure of all newly synthesized compounds was established by analytical and spectral data. Furthermore, the synthesized compounds were screened for antimicrobial activity by agar well-diffusion method. Some of the synthesized compounds showed appreciable antibacterial activity.